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Development of precision medicine

Using stem cells for wound healing

In this project, led by Cecilie Bredrup and Stian K. Almeland, the researchers are using mesenchymal stem cell transplantation to heal wounds of the eye and skin.

Chronic, non-healing, and large wounds are debilitating conditions that burden patients and healthcare systems. Advanced wound care developments involving cell-based therapies are emerging as promising treatment options. Mesenchymal stem cells (MSC) have many advantages for such use: they can be easily obtained, are easy to culture in vitro to clinical scales, can be cryopreserved without loss of potency, and allogenic MSC can be transplanted without the need for immunosuppression. 

 

Helsepersonell iført smittevernutstyr behandler pasient. Foto


This project will use current clinically approved protocols for autologous bone-marrow derived MSC and examine their effectiveness in selected groups of patients with wound healing problems of the skin and eye. Autologous MSC will be isolated and propagated at the Helse Bergen GMP approved Ex Vivo facility. This will secure a regulatory approved production pipeline from the point of harvesting bone marrow throughout production and delivery to patients in this project's phase I clinical trials. Treatment effect will be measured using sophisticated and innovative methods, developing a future biomarker program for cell therapy of wounds. In addition, preclinical experiments to evaluate the safety and efficacy of allogenic cells will be performed with the long-term aim of using these in clinical trials.​

 

Public​​ations

​Jenssen AB, Mohamed-Ahmed S, Kankuri E, Brekke RL, Guttormsen AB, Gjertsen BT, Mustafa K, Almeland SK. Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds. Eur. Burn J. 2022, 3, 493–516. (Review) https://doi.org/10.3390/ebj3040043​

Project participants​, Eye wound project 

Portrett Cecilie Bredrup. Foto

Specialist in Ophthalmology, Department of Ophthalmology, Haukeland University Hospital and
Associate Professor, Department of Clinical Medicine, University of Bergen

Portrait Titas Gladkauskas. Photo
 
 
 
Medical doctor and Ph.D. candidate, The Bergen Ophthalmogenetic Research Group, Department of Clinical Medicine, University of Bergen
 

Portrett Kamal Mustafa. Foto

Professor, Leader of the Tissue Engineering Research Group and Center of Translational Oral Research (TOR), Department of Clinical Dentistry (IKO), UiB​

 

Bjørn Tore Gjertsen

Photo: Ingvild Festervoll Melien

 
Professor, Department of Clinical Medicine, University of Bergen
 
Senior Consultant of Haematology at the Department Medicine, Haukeland University Hospital
 
Chief of Research, Haukeland University Hospital, Helse Bergen Health Trust

Portrett Eyvind Rødahl. Foto

Professor, Department of Clinical Medicine, University of Bergen and Department of Opthalmology, Haukeland University Hospital

 

Portrett Nils Bull. Foto
Photo: Bård Kjersem

 

 

Senior Consultant​, D​epartment of Opthalmology, Haukeland University Hospital

Portrett Hans Olav Ueland. Foto

Senior Consultant​, Department of Opthalmology, Haukeland University Hospital

Portrett Kathrine Halsøy. Foto

Senior Consultant​,​ Department of Opthalmology, Haukeland University Hospital

Portrett Cecilie Gjerde. Foto

Associate professor, Tissue Engineering Research Group, Department of Clinical Dentistry, UiB

​​

​​Project participants, Burn wound project 

 

Portrett Stian Kreken Almeland. Foto
Photo: Jørgen Barth

 

Consultant Plastic Surgeon, Norwegian National Burn Center, Dep. of Plastic, Hand, and Reconstructive Surgery, Haukeland University Hospital.
 
Associate Professor, Head of Research Group for Burn Care and Reconstructive Surgery, Department of Clinical Medicine and Center for Medical Education, University of Bergen.

Portrait Ragnvald Ljones Brekke. Photo

Consultant Plastic Surgeon / Head of Burns, Norwegian National Burn Center, Dep. of Plastic, Hand, and Reconstructive Surgery, Haukeland University Hospital

Portrait Anne Berit Guttormsen

Photo: Anders Lund


MD, dr. philos, DEAA, EDIC, Professor, Director of the Medical Student Research Program, Medical Faculty, University of Bergen.
 
Senior Consultant, Intensive Care Unit, Haukeland University Hospital.
 

Portrait Astrid Bjørke Jenssen. Photo

Doctor and researcher, Norwegian National Burn Center, Dep. of Plastic, Hand, and Reconstructive Surgery, Haukeland University Hospital

Portrait Samih Mohamed-Ahmed. Photo

Postdoctoral research fellow, Tissue Engineering group, Center of Translational Oral Research (TOR), Department of Clinical Dentistry (IKO), UiB






New grant - Cellu4Health

Recently, researchers in the Wound Healing-project and collaborators received a large grant for developing and validating an advanced biodegradable matrix and delivery system for treatment of severe burn injuries with mesenchymal stem cells (MSCs). 

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Last updated 5/27/2024